Vital Choices

Monday, June 12, 2006 Issue 78   VOLUME 3 ISSUE 78  
In This Issue
Three New Studies Bolster Mood Benefits of Omega-3s
Great Gifts for Dads Who Grill!
Beauty from a (Dark) Chocolate Bar?
Grilled Salmon Salad with Vinaigrette; Skewer-Grilled Lemongrass Halibut

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Publisher/Editor
Randy Hartnell
Producer
Craig Weatherby
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Grill Combo Packs for Perfect BBQ Parties


Our special Grilling Combo Packs provide the succulent centerpiece for fabulous barbeque feasts!

 

Grilling Special #1 - Alaskan Sockeye Fillets 

- 3 Whole Sockeye Fillets*

- Organic Salmon Marinade

- 6 Cedar Barbeque Planks

 

Grilling Special #2 - Wild Salmon Sampler

- 2 Sockeye portions**

- 2 King portions**

- 2 Silver portions**

- Organic Salmon Marinade

- 6 Cedar Barbeque

*total wt. at least 4.5 lbs.
**6-oz skinless-boneless fillets


Tataki = Tasty, Quick-Seared Salmon Sushi


Attention sushi lovers ... Vital Choice Tataki has arrived!

Tataki is the Japanese term for a lightly grilled, rare fillet ... in this case,
quick-seared, boneless sockeye salmon loins that are flash-frozen and individually vacuum-sealed.

 

Simply thaw your Tataki, slice and serve it solo, with salad, or with stir-fried veggies and rice for a quick, delicious, healthful meal. (Note: the loins may be cooked further to suit individual tastes.)


Sweet, Succulent "Salmon Candy"


Caught by Yu’pik Eskimos, then hand-boned and cut into strips, incomparably oil-rich King salmon is then brined in salt and organic brown sugar, and smoked using natural alder wood.

 

The taste is subtly sweet and unbelievably rich and flavorful! In fact, it’s so good we call it "salmon candy."


The World's Best Salmon Burgers!


Our Alaskan Sockeye Salmon Burgers are 99% pure wild Alaskan sockeye salmon and about 1% gluten-free organic ingredients, including rice flour, safflower oil, celery seed, rosemary extract and sea salt.

 

They're individually vacuum-sealed, cook from frozen in only 10 minutes, and make a quick healthy meal the kids will love.

 

Beware of imposters … you're not likely to find salmon burgers like these anywhere else!


Now Enjoy Smoked Sockeye Anywhere!




The positively seductive succulence of our premium hot-smoked sockeye salmon is now available in easy-traveling cans.

Savor a healthy, mouth-watering meal on the go!


Ivory King Salmon ... Savor a Rare Catch!


The rare and delectable Alaskan Ivory King Salmon is coveted by those who know king salmon best … the fishermen who catch them!

 

A quirk of nature graces us with a small portion of king salmon boasting ivory flesh marbled with vibrant pink and orange/red highlights.

 

Comparable to the red king in omega-3 content, our 6 oz skinless-boneless portions of troll-harvested Ivory King Salmon offer a medium-firm texture, sweet, rich flavor, and delightful eye appeal.


Got a Bright Idea?


Got an idea for a great new product or feature? Let us know! To send us your idea(s) click here, or visit our Web site for full contact information

 

If your idea is adopted, we’ll send you a $50 Vital Choice gift certificate!


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The Vital Choice Advantage



Click here to learn about the Vital Choice Advantage ... the many reasons why William Sears, M.D. — renowned as "America's Baby Doctor"— calls Vital Choice his favorite salmon source.


Vital Choice was founded by two longtime Alaska fishermen—Randy Hartnell and Dave Hamburg—who know where to get the highest quality fish.  And they test it periodically to ensure your safety.


 


Organic Berries!


Vital Choice fresh-frozen organic blueberries, strawberries and red raspberries are rich in anti-aging antioxidants, and draw customer comments like this:
“OH MY GOODNESS! I cannot believe the flavor ... the taste reminds me of something from my childhood. Thanks for a great product!

 

Berries are incredibly healthful foods, and it's smart to seek out organic berries, grown without synthetic pesticides.

 

Our organic berries come in convenient one pound bags, each yielding about 3-1/2 cups. They freeze well, so you can keep plenty on hand!


The World's First Unrefined Fish Oil



We put only whole, unrefined oil from wild Alaskan sockeye salmon in our 
premium salmon oil supplements. Wild Alaskan sockeye salmon is one of the cleanest fish in the sea: a trait reflected in the purity of our unrefined sockeye oil, which is now certified by NSF: one of the best-respected independent labs in the U.S.

Because our naturally pure salmon oil does not need to be distilled, it provides the essential omega-3 fatty acids (EPA & DHA), plus 30 other natural fatty acids and astaxanthin: the potent antioxidant that gives sockeye its distinctive deep-red color.

We use fish-gelatin capsules, and now offer our Salmon oil in liquid form for kids and others who have trouble swallowing pills. Last but not least, ours is the only salmon oil supplement certified as sustainably sourced by the Marine Stewardship Council (
www.msc.org).

Luscious Lox and More




Vital Choice smoked salmon is far superior to the preservative-laden farmed product found in most grocery stores.  

 

After curing in natural alder wood smoke, our Smoked Sockeye Portions and silky, cold-smoked Sliced Nova Lox are immediately vacuum-packed and flash-frozen.  Thawed and served, they taste as though they came fresh out of the smoker.

 

"I am in love with the hot-smoked salmon. It is fabulous flaked and scrambled with eggs and onions. They give the eggs a lovely zing." — Dana Jacobi, author of 12 Best Foods Cookbook.


Three New Studies Bolster Mood Benefits of Omega-3s
Leading psychiatric journal publishes positive evidence review re: anti-depression benefits of omega-3s, and positive preliminary research in childhood depression and adult suicide risk

Photo credit: bettyrocker.blogs.com

The effect of omega-3 fatty acids on mood took center stage this month, when the June issue of the American Journal of Psychiatry featured the positive results of three studies exploring aspects of a subject highly relevant to public health.

 

These findings add to the considerable body of evidence that supports the widely hypothesized association between mood disorders and three negative characteristics common to diets in developed countries:

 

1) Inadequate intake of omega-3s;

2) Correspondingly low tissue levels of omega-3s;

3) Excessive intake of omega-6 fatty acids, which compete with dietary omega-3s for inclusion in cell walls and influence on the metabolic pathways that exert profound effects on the myriad internal and external factors associated with all of the major degenerative diseases.

 

Study #1: Omega-3s may alleviate childhood depression

The Three Studies, in Brief

  • In a small clinical trial in depressed children aged 6-12 years, only those who received fish oil supplements enjoyed a major drop in depression.
  • A two-year pilot cohort study involving 30 suicide-prone psychiatric patients indicates that either low tissue levels of the omega-3 fatty acid DHA or a high ratio of omega-6 to omega-3 fatty acids predicts increased risk of suicide.
  • A new evidence review confirms that higher omega-3 intake can alleviate depression in people with low intake of omega-3s and excessive intake of omega-6 fatty acids. More research is needed on bipolar disorder and postpartum depression.

Some three percent of prepubescent children suffer from major depression: a small proportion that nonetheless adds up hundreds of thousands of miserable kids and even greater numbers of desperate parents and care givers.

 

Clinical studies in adolescent children indicate that about half receive some relief from treatment with either selective serotonin reuptake inhibitors (e.g., Prozac, Zoloft) or placebo pills.

 

However, these potent psychotropic drugs are not without their risks, and the efficacy of drug or nutrient treatment of prepubescent children is unknown. As the authors of this study said, “Major depressive disorder in children may be more common than previously thought, and its therapeutics are unclear.”

 

The authors had experienced success in a previous study testing the effects of omega-3s in depressed adults, so they decided to conduct a small “pilot” study in children between the ages of 6 and 12, to see whether omega-3s might help children as well.

 

The trial was conducted in Israel, at child psychiatry clinics in the Medical Center of Israel and the Beer-Sheva Mental Health Center. The researchers recruited 28 children, 20 of whom completed enough of the 16-week study for their data to be included.

 
Evaluations of the children’s status were made at the start and end of the study and at three points between. The Israeli team used two kinds of evaluation tools: tests administered and graded by the doctors, and self-evaluations done by the children.

 

Each child received 1,000 mg of fish oil daily, either in one dose or in two 500 mg doses, depending on their ability to swallow a larger capsule. The 1,000 mg fish oil capsules contained 400 mg of EPA and 200 mg of DHA. Combined, the two 500 mg fish oil capsules supplied slightly smaller amounts of omega-3s (380 mg of EPA and 180 mg of DHA).

 

The active and placebo capsules were identical except for a slight difference in color, which could be distinguished only by an experienced observer able to compare them simultaneously, and no child reported a fishy taste when asked specifically.

 


And as the graph above shows, the results were very encouraging: the depression-rating scores of the children who took the fish oil capsules dropped by 50 percent, while almost no positive effect was detected in the children taking the placebo capsules.

 

The Israelis came to these positive conclusions:

  • “The effect of omega-3 is highly significant. Among the children on omega-3 treatment, seven out of 10 had a greater than 50% reduction in CDRS [Childhood Depression Rating Scale test] scores. Of those on placebo, zero out of 10 had a greater than 50% reduction in CDRS scores ….”
  • “Four out of 10 children in the omega-3 group met the remission criteria of … a CDRS score [of less than] <29 at study exit; no subject in the placebo group met this criteria …”
  • “The self-rating CDI [Childhood Depression Inventory test] results were similar … CGI [Clinical Global Impression test] results were also highly significant.
  • “There were no clinically relevant side effects reported.”

This small, preliminary study holds strong promise that omega-3s might provide a safe adjunct treatment for depressed children, and its findings warrant further testing in a larger trial.

Study #2: Evidence for fish fats evaluated in three major mood disorders

The authors of this evidence review (Parker G 2006) hail from Australia’s Prince of Wales Hospital. They examined current evidence concerning the effect of dietary omega-3s on three common mood disorders: 1) depression (moderate to severe); 2) bipolar disorder (i.e., manic–depression); and 3) postpartum depression.

 

Rather than a formal statistical examination (i.e., meta-analysis), the Australian team sought only to detect general trends and identify data gaps. In addition to their generally positive conclusions, the authors call for studies designed to determine which omega-3 fatty acid—EPA or DHA—provides the greatest mood-enhancing benefit.

 

We’ve summarized their findings with regard to three mood disorders:

 

Depression: strong evidence of benefit

Several months before the current evidence review, the authors of another evidence review (Sontrop J 2005) had this to say about omega-3s and depression: “The relationship between ... [omega-3s] ... and depression is biologically plausible and is consistent across study designs, study groups, and diverse populations, which increases the likelihood of a causal relationship.”

 

Likewise, the authors of the current review (Parker G 2006) concluded that most evidence shows omega-3s can exert therapeutic effects in depressed people, and that higher seafood consumption and higher tissue levels of fish-borne omega-3s yield reduced rates of mood disorders.

 

While they identified one recent clinical study in which supplemental omega-3s produced no apparent positive effect on depression (Hakkarainen R 2004), they noted two likely reasons for this unusual failure, and proposed an intriguing explanation related to the successful outcome of a Finnish omega-3/depression study in women (Timonen M 2004):

 

  • The subjects’ intake of EPA and DHA—the long-chain omega-3s used and found effective in almost all depression studies—was less than 0.5 grams (500 mg) per day (experts recommend getting at least 660 mg per day);
  • Most of the omega-3 fatty acids consumed by the men in this negative study was alpha-linolenic acid; the form found in plants, only 5–15 percent of which gets converted into the long-chain “marine” forms essential to brain function (EPA and DHA).
  • The negative findings of this male-only cohort study could be related to gender, since the results of a recent study in Finland showed that low fish consumption was only associated with depression in women. The Finns’ finding may mark the discovery of a distinction in the two gender’s degree of need for dietary omega-3s vis-à-vis depression-prevention. (The Australian evidence-reviewers noted that these results could indicate differences in the ways the two genders metabolize neurotransmitters and phospholipids.)

Bipolar Disorder (manic-depression): possibility of benefit; more study needed

The evidence with regard to this disorder—in which patients swing from depressed to hyperactive “manic” states—is less abundant and less clear than for “regular” depression. The results of two studies indicate that omega-3 supplements may help patients with bipolar disorder, but it remains to seen whether these possible benefits stem from some mood-stabilizing propensity of omega-3s or simply from their documented anti-depressant effect.

 

Postpartum Depression: mixed evidence; plausible rationale; more study needed

While the worldwide average rate of postpartum depression is 12.4 percent, national rates vary nearly 50-fold, from just 0.5 percent of mothers in affluent, seafood-loving Singapore to a horrifically high 24.5 percent of mothers in poverty-stricken South Africa.

 

We’ve reported the mixed results of small, “pilot” clinical trials that sought to determine the preventive effect of dietary omega-3s (see “New Study Supports Omega-3 Therapy in Post-Partum Depression”).

 

The authors of the current review note two things:

  1. Studies in women and animals indicate that it is safe for them to take omega-3 supplements during pregnancy and the postpartum period;
  2. The results of a cross-national analysis by leading clinician and omega-3 researcher Joe Hibbeln, M.D. (Hibbeln JR 2002) show that both higher seafood consumption and higher DHA content in the mothers’ breast milk predicted a lower risk of postpartum depression, and that higher reported seafood consumption predicted a higher DHA content in the mothers’ milk.

The Australian evidence-review team noted that omega-3 intake is likely to play a role in postpartum depression since, during the third trimester, the fetus accumulates an average of 67 mg of DHA per day, which is more than many women consume from fish or supplements (Innis SM 2003). For such women, transfer of DHA to the baby through the placenta and breast milk poses a risk of significant depletion of their own omega-3s during pregnancy and nursing, which could raise their risk of postpartum depression.

 

Study #3: Higher omega-3 tissue levels may reduce suicide attempts

Psychiatrist and omega-3 researcher Joe Hibbeln, M.D. is Chief of the Outpatient Clinic in the Laboratory of Clinical Studies at the National Institute on Alcohol Abuse and Alcoholism in Bethesda, Maryland. We had the opportunity to hear him speak, and then speak with him at length, during last year’s Seafood & Health conference and at Dr. Andrew Weil’s Nutrition & Health conference in March of this year.

 

One of the studies published in the June issue of the American Journal of Psychiatry—which took place in Dr. Hibbeln’s clinic—compared the relationship between the tissue levels of omega-3s in seriously depressed patients and the rate at which they attempted suicide.

 
Dr. Hibbeln’s team recruited 33 adults seeking treatment for major depression who were free of any neurological or medical disease or substance dependence and were off antidepressant medications for at least 14 days prior to the start of the study.

 

His clinic has a reputation for suicide research and treatment of suicidal patients and attracts a high proportion of suicide attempters. Just over half of the subjects had a history of previous suicide attempt, and upon admission, most had failed recent depression treatment.

 

At the outset, the subjects’ blood levels of omega-3s (EPA and DHA) and the ratios of omega-6 to omega-3 fatty acids in their blood were recorded. The volunteers received inpatient (8 weeks) or outpatient (6 months) treatment from the research team, followed by community-based treatment.

 


Evaluations were performed at three, 12, and 24 months (by raters unaware of the subjects’ omega-3 status), with "time-to-subsequent-suicide-attempt" as the outcome against which the suicide-prevention power of higher
blood levels of omega-3s would be measured. In addition, the results were adjusted to account for any medications prescribed during the follow-up period, and the subjects’ individual attributes.

 

Three of the 33 subjects dropped out, 23 did not attempt suicide, and seven made at least one suicide attempt, of which two were fatal.

 

As the research team concluded, “Lower docosahexaenoic acid [omega-3 DHA] percentages of total phospholipid fatty acids [i.e., tissue concentrations of DHA] … and higher omega-6/omega-3 ratio predicted subsequent suicide attempts …”

 

That is, with all other factors being equal, the subjects with the lowest blood levels of omega-3 DHA were the quickest to attempt suicide.  

 

In addition, the subjects’ fatty acid status predicted the "time-to-subsequent-suicide-attempt" period, regardless of treatment with drugs or other therapies. In other words, the effects of low DHA blood levels or high omega-6/omega-3 ratios with regard to the main outcome measure—time to suicide attempt—were not altered by adjusting for the number of medications prescribed during the follow-up period.

 

Sources

  • Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry. 2006 Jun;163(6):1098-100. 
  • Parker G, Gibson NA, Brotchie H, Heruc G, Rees AM, Hadzi-Pavlovic D. Omega-3 Fatty acids and mood disorders. Am J Psychiatry. 2006 Jun;163(6):969-78.
  • Sublette ME, Hibbeln JR, Galfalvy H, Oquendo MA, Mann JJ. Omega-3 polyunsaturated essential Fatty Acid status as a predictor of future suicide risk. Am J Psychiatry. 2006 Jun;163(6):1100-2.
  • Hakkarainen R, Partonen T, Haukka J, Virtamo J, Albanes D, Lonnqvist J: Is low dietary intake of omega-3 fatty acids associated with depression? Am J Psychiatry 2004; 161:567–569.
  • Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Räsänen P: Fish consumption and depression: the Northern Finland 1966 birth cohort study. J Affect Disord 2004; 82:447–452
  • Colin A, Reggers J, Castronovo V, Ansseau M. [Lipids, depression and suicide] Encephale. 2003 Jan-Feb;29(1):49-58. Review. French.
  • Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H. Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J Affect Disord. 1996 Apr 26;38(1):35-46.
  • Huan M, Hamazaki K, Sun Y, Itomura M, Liu H, Kang W, Watanabe S, Terasawa K, Hamazaki T. Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry. 2004 Oct 1;56(7):490-6. 
  • Sontrop J, Campbell MK. Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique. Prev Med. 2006 Jan;42(1):4-13. Epub 2005 Dec 7. Review.
  • Colin A, Reggers J, Castronovo V, Ansseau M. [Lipids, depression and suicide] Encephale. 2003 Jan-Feb;29(1):49-58. Review. French.
  • Pouwer F, Nijpels G, Beekman AT, Dekker JM, van Dam RM, Heine RJ, Snoek FJ. Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence. Diabet Med. 2005 Nov;22(11):1465-75. Review.
  • Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71. Erratum in: E Neuropsychopharmacol. 2004 Mar;14(2):173.
  • Edwards R, Peet M, Shay J, Horrobin D. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord. 1998 Mar;48(2-3):149-55.
  • Freeman MP. -3 fatty acids in psychiatry: a review. Ann Clin Psychiatry. 2000 Sep;12(3):159-65. Review.
  • Rees AM, Austin MP, Parker G. Role of omega-3 fatty acids as a treatment for depression in the perinatal period. Aust N Z J Psychiatry. 2005 Apr;39(4):274-80. Review.
  • Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MM. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr. 2003 Jul;78(1):40-6. 
  • Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M, Gelenberg AJ. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr Scand. 2006 Jan;113(1):31-5.
  • Sontrop J, Campbell MK. Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique. Prev Med. 2006 Jan;42(1):4-13. Epub 2005 Dec 7. Review.
  • Rees AM, Austin MP, Parker G. Role of omega-3 fatty acids as a treatment for depression in the perinatal period.
  • Aust N Z J Psychiatry. 2005 Apr;39(4):274-80. Review.
  • Dennis CL. Preventing postpartum depression part I: a review of biological interventions. Can J Psychiatry. 2004 Jul;49(7):467-75. Review.
  • Chiu CC, Huang SY, Su KP. Omega-3 polyunsaturated fatty acids for postpartum depression.
  • Am J Obstet Gynecol. 2004 Feb;190(2):582-3; author reply 583. Marangell LB, Martinez JM, Zboyan HA, Chong H, Puryear LJ. Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. Depress Anxiety. 2004;19(1):20-3.
  • Otto SJ, de Groot RH, Hornstra G. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins Leukot Essent Fatty Acids. 2003 Oct;69(4):237-43.
  • Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. Am J Obstet Gynecol. 2003 May;188(5):1348-53.
  • Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord. 2002 May;69(1-3):15-29.
  • Innis SM. Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr 2003; 143(4 suppl):S1-S8

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