Vital Choices Newsletter

Monday, March 1, 2010 Issue 344  

In This Issue
Vital Bonus Options Feb. 25 - March 3
Middle-Aged Brain Boost Linked to Omega-3s
Antioxidant-Rich Diets Linked to Lower Diabetes Risk
Wild Salmon Tacos or Burritos
Omega-3s Boost Boys’ Brains in MRI Scans

NEW Certified for Sport™ Salmon Oil + Vitamin D3
 

 
Omega-3s and Vitamin D support the special physical and mental demands placed on serious amateur and professional athletes.
 
So that they can benefit from both nutrients worry-free, we sought the prized Certified for Sport™ seal of approval from NSF, which assures athletes that our NEW Certified for Sport™ Sockeye Salmon Oil + Vitamin D3 is free of contaminants and all substances banned by sports federations worldwide.
 
• Fish-gelatin softgels 
• Potency & purity certified by NSF
• 1000 IU of Vitamin D3 per softgel
• 200mg total Omega-3s per softgel
• No artificial additives, colors, or preservatives
• No dairy, starch, wheat, yeast, sugar, or soy

Free Bonus Options
February 25 to March 3

Choose from among our Bonus Options ...
... then start shopping to earn your reward!
 
Wild Red Sockeye Salmon
 
Alaskan Halibut
 
Omega-3 Salmon Oil
 
Organic EV Olive Oil
 
Dried Organic Cranberries
 
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... all offers include Free Shipping!


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Utterly Unique ... Vitamin D in Salmon Oil
 
We are pleased to introduce a high-quality, higher-potency vitamin D supplement … one with unique attractions!
 
Each tiny, 300 mg softgel capsule of Vital Choice Vitamin D3 in Wild Sockeye Salmon Oil provides a generous 2,000 International Units (IU) of vitamin D3.
 
D3 is the preferred, natural form of this amazing vitamin, and ours is certified pure and potent by NSF .
 
Better yet, our D3 comes in a base of whole, unrefined, certified-pure, sockeye salmon oil, certified sustainable by the MSC .
 
Each Vitamin D3 softgel contains 45mg of omega-3s, but health authorities recommend 500mg of omega-3s per day, so it doesn't replace fish oil.
 
A 3,000mg daily serving of our Sockeye Salmon Oil provides 460mg, so if you also take one Vitamin D3 in Salmon Oil softgel per day, that would bring your supplemental omega-3 intake to a perfect 505mg!

World's Finest Fish Oil



Our "whole food"
Omega-3 Salmon Oil supplements contain only unrefined oil from wild Alaska Sockeye Salmon: a fish whose renowned purity is reflected in the pristine contents of our naturally colorful capsules.

Unlike standard fish oils, our naturally pure Sockeye Salmon Oil does not need to be chemically refined: a process that can damage omega-3s. Instead, our oil's 
purity and potency are certified by NSF.

As a result, our whole, unrefined Sockeye Salmon Oil retains all of the omega-3s (EPA & DHA), vitamin D, phospholipids, and fatty acids natural to whole Sockeye Salmon. 

The rich orange hue of our Salmon Oil comes from its natural complement of astaxanthin: the super-potent antioxidant pigment that gives Sockeye their distinctive color and protects our Salmon Oil's abundant omega-3s from oxidation.

In addition, ours was the first Salmon Oil supplement certified as sustainably sourced by the Marine Stewardship Council
.

We encapsulate our Salmon Oil in pure fish gelatin, and offer special varieties for special needs:

 Smaller Softgels (500 mg)
 
Liquid Salmon Oil for children and folks who may have trouble swallowing our 1,000 mg softgels
 
Lemon-Flavored Salmon Oil for folks who experience bounce-back.



Vital Choice Salmon Oil (top left) vs. two standard fish oils


Middle-Aged Brain Boost Linked to Omega-3s
Findings add weight to calls for more clinical trials to test the brain-health effects of omega-3 fatty acids in people of all ages
by Craig Weatherby

Click for full story and printer friendly version
Books, articles, and TV shows about brain aging have been sprouting up lately … and most mention the growing evidence that omega-3s boost adults’ brain health.
 
This perception was affirmed by the University of Pittsburgh team behind the study we report today:
“Existing evidence links greater dietary intake of fish and omega-3s to better early brain development and lowered risk of cognitive disorders in late life.” (Muldoon MF et al. 2010)
 
The results of their unusually compelling new study strengthen the suspected link between omega-3s and brain health … while shedding light on the oft-overlooked brain effects of omega-3s in people’s mid-adulthood years (35 to 54).
 
This investigation is more meaningful than most epidemiological studies because it was based on omega-3 blood tests, not estimates of omega-3 intake based on diet surveys.
 
Key points
  • Study in people aged 35 to 54 links higher blood levels of omega-3 DHA to better performance on cognition tests.
  • Findings add to small body of evidence that omega-3s can do more than deter, delay, or diminish dementia in people over 65.
  • Results need to be confirmed in clinical trials and should encourage funding for them.
Analyses based on blood tests still can’t prove a cause-and-effect relationship between omega-3s and brain health. But they’re far better than basing a statistical analysis on people’s iffy answers to diet questionnaires.
 
And unlike most epidemiological studies on omega-3s and brain health, it involved people in mid-adulthood, aged 35 to 54 … so the evidence it provides is especially interesting.
 
Relatively few studies have examined the effects of omega-3s in this “young middle age” bracket, with mixed but generally favorable results (Kalmijn S et al. 2004; Fontani G et al. 2005; Eskelinen MH et al. 2008; Devore EE et al. 2009).
 
We’ve also reported on other evidence that omega-3s may enhance brain health and performance in people from 20 to 50:
 
Let’s take a look at the new findings, which add force to the increasing calls for clinical trials.
 
Blood analysis links omega-3 DHA to better brain function in middle age
Researchers from the University of Pittsburgh analyzed health records and blood tests from 280 people aged 35 to 54 (Muldoon MF et al. 2010).
 
Why this epidemiological study was better than most
In all but a few epidemiological studies, people are surveyed about their eating habits in order to estimate their intake of a nutrient being studied for possible health effects ... in this case, omega-3s.
 
The accuracy of this approach relies on several factors prone to error: the quality of the diet survey and the omega-3-intake estimates it yields, the size of the study population, the number of years being recalled … and people’s fuzzy memories.
 
Also, higher intakes of healthier foods can be a marker for other healthy lifestyle factors (e.g., vigorous exercise and mental work) that affect brain health.
 
The uncertainties introduced by these so-called “confounding factors” make it hard to tell whether higher intakes of nutrients such as omega-3s are really responsible for any health benefits that are statistically associated with them.
 
Occasionally, researchers like the Pittsburgh team behind this new study have something better to base their analysis on … access to blood samples taken from the participants.
The participants were mentally and physically healthy, and were not taking fish oil or omega-3 supplements. Thus, the omega-3s in their blood came from foods.
 
The analysis sought associations between blood levels of three different omega-3 fatty acids – ALA, EPA, and DHA – and five measures of cognitive functioning, based on the results of neuropsychological tests.
 
(EPA and DHA are the long-chain omega-3s found in fish fat, while ALA is the short-chain omega-3 found in green plants. The body burns most dietary ALA for its calories, and converts only about two to 10 percent of it into EPA and DHA … the two omega-3s proven essential to child development, key immune functions, and brain and eye health.)
 
Specifically, the Pittsburgh team was looking to see whether higher blood levels of any of these three omega-3 fats were associated with better or worse “non-verbal reasoning” and “working” memory in people between 35 and 54.
 
Non-verbal reasoning is the ability to identify relationships between shapes and patterns, visual sequences, and objects. Working memory is required for the integration, processing, disposal, and retrieval of information.
 
Of the three omega-3s, DHA is most closely associated with brain function. DHA constitutes some 60 percent of the fat in the brain, and it’s a key structural and functional component of brain cell membranes.
 
And as we would have expected, DHA was the winner: “[A] higher DHA [blood level] was related to better performance on tests of nonverbal reasoning and mental flexibility, working memory, and vocabulary.” (Muldoon MF et al. 2010)
 
Importantly, the researchers detected a “dose-response” relationship between omega-3 DHA and better brain function … a finding that raises the likelihood that omega-3 DHA really was responsible for the brain benefits the scientists observed.
 
In contrast, higher blood levels of EPA and ALA were not associated with better cognitive performance. This is not very surprising, since neither of these omega-3 fatty acids is as closely associated as DHA with brain health.
 
The authors had this to say about the significance of their results: “These findings suggest that DHA is related to brain health throughout the lifespan ...” (Muldoon MF et al. 2010)
 
That is, in addition to helping deter, delay, or diminish dementia among people aged 65 or more, omega-3 DHA from fish fat may boost basic brain powers in younger adults.
 
Authors call for more research
As we note in our sidebar (see “Why this epidemiological study was better than most”), this kind of study has limitations… a caveat the authors expressed:
“The findings from these analyses … cannot establish that any association between the omega-3 fatty acids cognitive performance is causal.” (Muldoon MF et al. 2010)
 
Accordingly, even as they affirmed the existence of considerable evidence for the presumed brain benefits of omega-3s, they underlined the need for clinical trials:
“While this and prior observational studies of omega-3 fatty acids and cognitive function have generally found [positive] associations [with brain health] that withstand adjustment for obvious confounding [diet/lifestyle] factors … randomized clinical trials in both healthy and clinical [populations] are warranted.” (Muldoon MF et al. 2010)
 
Is anyone in charge at NIH listening? We hope so!
 
 
Sources
  • Devore EE, Grodstein F, van Rooij FJ, Hofman A, Rosner B, Stampfer MJ, Witteman JC, Breteler MM. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr. 2009 Jul;90(1):170-6. Epub 2009 May 27.
  • Eskelinen MH, Ngandu T, Helkala EL, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M. Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study. Int J Geriatr Psychiatry. 2008 Jul;23(7):741-7.
  • Fontani G, Corradeschi F, Felici A, Alfatti F, Bugarini R, Fiaschi AI, Cerretani D, Montorfano G, Rizzo AM, Berra B. Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acids. Eur J Clin Invest. 2005 Aug;35(8):499-507.
  • Fontani G, Corradeschi F, Felici A, Alfatti F, Bugarini R, Fiaschi AI, Cerretani D, Montorfano G, Rizzo AM, Berra B. Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acids. Eur J Clin Invest. 2005 Aug;35(8):499-507.
  • Kalmijn S, van Boxtel MP, Ocké M, Verschuren WM, Kromhout D, Launer LJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology. 2004 Jan 27;62(2):275-80.
  • Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol. 2005 Dec;62(12):1849-53. Epub 2005 Oct 10.
  • Muldoon MF, Ryan CM, Sheu L, Yao JK, Conklin SM, Manuck SB. Serum Phospholipid Docosahexaenonic Acid Is Associated with Cognitive Functioning during Middle Adulthood. J Nutr. 2010 Feb 24. [Epub ahead of print] doi:10.3945/jn.109.119578
  • van de Rest O, Spiro A 3rd, Krall-Kaye E, Geleijnse JM, de Groot LC, Tucker KL. Intakes of (n-3) fatty acids and fatty fish are not associated with cognitive performance and 6-year cognitive change in men participating in the Veterans Affairs Normative Aging Study. J Nutr. 2009 Dec;139(12):2329-36. Epub 2009 Oct 14.
  • van Gelder BM, Tijhuis M, Kalmijn S, Kromhout D. Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr. 2007 Apr;85(4):1142-7.
 

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